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Patricia L Opresko Selected Research

RecQ Helicases

1/2014Human RecQ helicases in DNA repair, recombination, and replication.
8/2012Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequences.
8/2008Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase.
1/2008Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases.
7/2007Role for the Werner syndrome protein in the promotion of tumor cell growth.
9/2005POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates.
6/2004The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2.
5/2004Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.
11/2003Werner protein stimulates topoisomerase I DNA relaxation activity.

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Patricia L Opresko Research Topics

Disease

23Werner Syndrome (Werner's Syndrome)
08/2012 - 05/2003
16Neoplasms (Cancer)
11/2021 - 05/2003
10Premature Aging
08/2012 - 12/2003
7Genomic Instability
01/2021 - 11/2003
3Carcinogenesis
11/2017 - 11/2003
2Bloom Syndrome
09/2005 - 10/2002
2Hypersensitivity (Allergy)
05/2004 - 12/2003
1Colorectal Neoplasms (Colorectal Cancer)
10/2020
1Pancreatic Neoplasms (Pancreatic Cancer)
10/2020
1Inflammation (Inflammations)
10/2019
1Mitochondrial Diseases (Mitochondrial Disease)
10/2019
1Rectal Neoplasms (Rectal Cancer)
01/2019
1Ataxia Telangiectasia (Louis Bar Syndrome)
12/2014
1XFE Progeroid Syndrome
11/2011
1Progeria (Hutchinson Gilford Syndrome)
11/2011
1Cataract (Cataracts)
06/2011
1Osteosarcoma (Osteogenic Sarcoma)
10/2006
1Ataxia (Dyssynergia)
04/2006
1Inborn Genetic Diseases (Disease, Hereditary)
05/2004
1Nijmegen Breakage Syndrome
05/2004
1BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
09/2003

Drug/Important Bio-Agent (IBA)

23Proteins (Proteins, Gene)FDA Link
08/2012 - 05/2003
9RecQ HelicasesIBA
01/2014 - 11/2003
7Telomerase (Telomerase Reverse Transcriptase)IBA
11/2021 - 11/2016
7DNA (Deoxyribonucleic Acid)IBA
01/2021 - 12/2003
4Exonucleases (3' 5' Exonuclease)IBA
11/2011 - 10/2006
2EnzymesIBA
01/2021 - 12/2016
2Phosphotransferases (Kinase)IBA
12/2014 - 09/2003
2chromium hexavalent ionIBA
06/2010 - 08/2009
2DNA Polymerase beta (DNA Polymerase IV)IBA
01/2006 - 06/2003
1NucleotidesIBA
11/2021
18-hydroxyguanineIBA
01/2021
1NucleoproteinsIBA
01/2021
1Biomarkers (Surrogate Marker)IBA
10/2020
1RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
10/2020
1Reactive Oxygen Species (Oxygen Radicals)IBA
10/2019
1CI 22IBA
01/2019
1ProteomeIBA
11/2016
1Nuclear Proteins (Protein, Nuclear)IBA
11/2011
1Staphylococcal Protein A (Protein A)IBA
11/2011
1DNA HelicasesIBA
12/2009
1Replication Protein AIBA
12/2009
1CarcinogensIBA
08/2009
1Histones (Histone)IBA
10/2006
1Mitomycin (Mitomycin-C)FDA LinkGeneric
05/2004
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
12/2003
1Bleomycin (Blenoxane)FDA LinkGeneric
09/2003
1Imatinib Mesylate (Gleevec)FDA Link
09/2003
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
09/2003
1Tyrosine (L-Tyrosine)FDA Link
09/2003
1Telomere-Binding ProteinsIBA
10/2002

Therapy/Procedure

3Therapeutics
11/2021 - 08/2014
1Lenses
06/2011